For a complete list of publications, go to PubMed.

 

Research Papers:

Theodore CJ, Wagner LH, and Campellone KG (2024).  Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity.  In revision at Mol Biol Cell.  bioRxiv doi: 10.1101/2024.03.12.584718.

Coulter AM⁼, Cortés V⁼, Theodore CJ, Cianciolo RE, Korstanje R, and Campellone KG (2024).  WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration.  Mol Biol Cell. 35:ar80.  doi: 10.1091/mbc.E24-01-0025.

King VL and Campellone KG (2023).  F-actin-rich territories coordinate apoptosome assembly and caspase activation during DNA damage-induced intrinsic apoptosis. Mol Biol Cell  15:mbcE22040119. doi: 10.1091/mbc.E22-04-0119.

Haarer EL, Theodore CJ, Guo S, Frier RB, and Campellone KG (2023).  Genomic instability caused by Arp2/3 complex inactivation results in micronucleus biogenesis and cellular senescence.  PLoS Genetics  19:e1010045. doi: 10.1371/journal.pgen.1010045.

King VL, Leclair NK, Coulter AM, and Campellone KG (2021).  The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis.  PLoS Genetics  17:e1009512. doi: 10.1371/journal.pgen.1009512.

Kabrawala S, Zimmer MD, and Campellone KG (2020).  WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility.  PLoS Genetics.  16:e1008694.

Velle KB and Campellone KG (2018).  Enteropathogenic E.coli relies on collaboration between the formin mDia1 and the Arp2/3 complex for actin pedestal biogenesis and maintenance.  PLoS Pathogens. 14:e1007486 Epub.

Velle KB and Campellone KG (2017).  Extracellular motility and cell-to-cell transmission of enterohemorrhagic E. coli is driven by EspF_U-mediated actin assembly.  PLoS Pathogens. 13:e1006501 Epub.

Mathiowetz AJ, Baple E, Russo AJ, Coulter AM, Carrano E, Brown J, Jinks RN, Crosby AH, and Campellone KG (2017).  An Amish founder mutation disrupts a PI(3)P-WHAMM-Arp2/3 complex driven autophagosome remodeling pathway.  Mol Biol Cell. 28(19):2492-2507.  [Highlighted Article]

Russo AJ, Mathiowetz AJ, Hong S, Welch MD, and Campellone KG (2016).  Rab1 recruits the actin nucleation machinery but limits filament assembly during membrane remodeling.  Mol Biol Cell. 27(6):967-978.  [Featured on the Cover]

Borinskaya S, Velle KB, Campellone KG, Talman A, Alvarez D, Agaisse H, Wu YI, Loew LM, and Mayer BJ (2016).  Integration of linear and dendritic actin nucleation in Nck-induced actin comets.  Mol Biol Cell. 27(2):247-259.

Jinks RN, Puffenberger EG, Baple E, Harding B, Crino P, Fogo AB, Wenger O, Wang H, Xin B, Koehler AE, McGlincy MH, Provencher MM, Smith JD, Tran L, Turki SA, Chioza BA, Cross H, Gerety SS, Harlalka GV, Hurles ME, Maroofian R, Heaps AD, Morton MC, Stempak L, Hildebrandt F, Sadowski CE, Zaritsky J, Campellone K, Morton DH, Wang H, Crosby A, and Strauss KA (2015). Recessive nephrocerebellar syndrome on the Galloway-Mowat syndrome spectrum is caused by homozygous protein-truncating mutations of WDR73.  Brain.  138: 2173-2190.

Shen QT, Hsiue PP, Sindelar CV, Welch MD, Campellone KG*, and Wang HW* (2012).  Structural insights into WHAMM-mediated cytoskeletal coordination during membrane remodeling.  J Cell Biol. 199(1):111-124.  [Featured on the Cover]

Campellone KG, Siripala AD, Leong JM, and Welch MD (2012). Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.  J Biol Chem. 287(24):20613-20624.

Huang J, Birmingham CL, Shahnazari S, Shiu J,  Zheng YT, Smith AC, Campellone KG, Heo WD, Gruenheid S, Meyer T, Welch MD, Ktistakis NT, Kim PK, Klionsky DJ, and Brumell JH.  (2011) Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires the Rab1 GTPase.  Autophagy.  7(1):17-26.

Vingadassalom D*, Campellone KG*, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, and Leong JM (2010).  Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspF_U-mediated actin pedestal formation. PLoS Pathog. 6:e1001056 Epub.

Campellone KG, Cheng HC, Robbins D, Siripala AD, McGhie EJ, Hayward RD, Welch MD, Rosen MK, Koronakis V, and Leong JM (2008).  Repetitive N-WASP-binding elements of the enterohemorrhagic E. coli effector EspF_U synergistically activate actin assembly. PLoS Pathog. 4:e1000191 Epub.

Cheng HC, Skehan BM, Campellone KG, Leong JM, and Rosen MK (2008).  Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF_U.  Nature. 454(7207):1009-1013.

Campellone KG, Webb NJ, Znameroski EA, and Welch MD (2008).  WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Cell.  134(1):148-161.  [Featured on the Cover]

Ritchie JM, Brady MJ, Riley KN, Ho TD, Campellone KG, Herman IM, Donohue-Rolfe A, Tzipori S, Waldor MK, and Leong JM (2007).  EspF_U, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7. Cell Microbiol. 10(4):836-847.

Brady MJ, Campellone KG, Ghildiyal M, and Leong JM (2007).  Enterohaemorrhagic and enteropathogenic Escherichia coli Tir proteins trigger a common Nck-independent actin assembly pathway.  Cell Microbiol. 9(9):2242-2253.

Campellone KG, Roe AJ, Lobner-Olesen A, Murphy KC, Magoun L, Brady MJ, Donohue-Rolfe A, Tzipori S, Gally DL, Leong JM, and Marinus MG (2007).  Increased adherence and actin pedestal formation by dam-deficient enterohaemorrhagic Escherichia coli O157:H7.  Mol Microbiol. 63(5):1468-1481.

Campellone KG, Brady MJ, Alamares JG, Rowe DC, Skehan B, Tipper DJ, and Leong JM (2006).  Enterohemorrhagic Escherichia coli Tir requires a C-terminal 12-residue peptide to initiate EspF_U-mediated actin assembly and harbors N-terminal sequences that influence pedestal length.  Cell Microbiol. 8(9):1488-1503.

Campellone KG and Leong JM (2005).  Nck-independent actin assembly is mediated by two phosphorylated tyrosines within enteropathogenic Escherichia coli Tir.  Mol Microbiol. 56(2): 416-432.

Campellone KG, Robbins D, and Leong JM (2004).  EspF_U is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly. Dev Cell. 7(2): 217-228.  [Featured Article]

Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, and Leong JM (2004).  Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly.  J Cell Biol. 164(3): 407-416.

Murphy KC, and Campellone KG (2003).  Lambda Red-mediated recombinogenic engineering of enterohemorrhagic and enteropathogenic E. coli. BMC Mol Biol. 4:1-11.3.

Liu H, Radhakrishnan P, Magoun L, Prabu M, Campellone KG, Savage P, He F, Schiffer CA, and Leong JM (2002).  Point mutants of EHEC intimin that diminish Tir recognition and actin pedestal formation highlight a putative Tir binding pocket.  Mol Microbiol. 45(6): 1557-1573.

Campellone KG, Giese A., Tipper DJ, and Leong JM (2002).  A tyrosine-phosphorylated 12-amino-acid sequence of enteropathogenic Escherichia coli Tir binds the host adaptor protein Nck and is required for Nck localization to actin pedestals.  Mol Microbiol. 43(5): 1227-1241.

Murphy KC, Campellone KG, and Poteete AR (2000).  PCR-mediated gene replacement in Escherichia coli.  Gene. 246(1-2): 321-330.

 

Review Articles:

Campellone KG, Lebek NM, King VL (2023).  Branching out in different directions: Emerging cellular functions for the Arp2/3 complex and WASP-family actin nucleation factors. Eur J Cell Biol  102:151301. doi: 10.1016/j.ejcb.2023.151301.

Coulter AM and Campellone (2021).  Microbe-Cytoskeleton Interactions.  Encyclopedia of  Biological Chemistry, 3rd Edition.

Lebek NM and Campellone KG (2020).  Adding SNX to the mix: SNX9 drives filopodia biogenesis.  J Cell Biol.  219:e202002086.

Gupton SL and Campellone KG (2018).  Actin dynamics and function.  Mol Biol Cell.  29(6): 696-697.

Rottner K, Hanisch J, and Campellone KG (2010).  WASH, WHAMM, and JMY:  Regulation of Arp2/3 complex and beyond.  Trends Cell Biol.  20(11): 650-661.

Campellone KG (2010).  Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic E. coli: Tir, EspF_U, and actin pedestal assembly.  FEBS J.  277(11): 2390-402.

Campellone KG and Welch MD. (2010).  A nucleator arms race: Cellular control of actin assembly.  Nat Rev Mol Cell Biol. 11(4): 237-251.

Campellone KG (2010).  Phosphoinositides influence pathogen surfing: EPEC rights the SHIP.  Cell Host Microbe 7(1):1-2.

Hayward RD, Leong JM, Koronakis V and Campellone KG (2006).  Exploiting pathogenic Escherichia coli to model transmembrane receptor signaling.  Nat Rev Microbiol.  4(5):358-370.

Campellone KG and Leong JM (2003).  Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157:H7.  Curr Opin Microbiol.  6(1):82-90.

 

Methods Chapters:

Campellone KG and Coulter AM (2021).  Lambda Red mediated recombination in Shiga toxin-producing Escherichia coli (STEC).  Methods Mol Biol.  2291: 145-162.

Savage PJ, Campellone KG, Leong JM (2007).  Interaction of enterohemorrhagic Escherichia coli (EHEC) with mammalian cells: cell adhesion, type III secretion, and actin pedestal formation. Current Protocols in Microbiology. Chapter 5: Unit 5A 1.